Discovery of Glycosylation related Biomarkers
Changes from normal to abnormal cell function (e.g. during disease) are proximately linked to the changes in glycosylation. For example, alterations in N-acetylneuraminic acid and fucose in glycan structures were found to be present in cystic fibrosis, and changes in N-acetylneuraminic acid are related to breast cancer and sialuria. Thus knowledge of the function and structure of glycans is proving beneficial for disease diagnosis, monitoring (Biomarkers), treatments (vaccines and pharmaceuticals) and in providing solutions to basic biological problems. Up to date, the discovery of glycosylation related Biomarkers is still in its infancy. One of our research targets is to discover the relationship between the change of specific glycan structures and certain commonly regonized biological disorders.